FIP1L1

FIP1L1
Identifiers
Aliases	FIP1L1, FIP1, Rhe, hFip1, factor interacting with PAPOLA and CPSF1
External IDs	OMIM: 607686 HomoloGene: 134000 GeneCards: FIP1L1
Gene location (Human)
Chr.	Chromosome 4 (human)
End	53,460,862 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; ganglionic eminence; ; internal globus pallidus; ; stromal cell of endometrium; ; canal of the cervix; ; right lung; ; left lobe of thyroid gland; ; minor salivary gland; ; left adrenal gland;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding;
Cellular component	nucleus; nucleoplasm; mRNA cleavage and polyadenylation specificity factor complex;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA processing; mRNA 3'-end processing; mRNA export from nucleus; mRNA polyadenylation; pre-mRNA cleavage required for polyadenylation;
	Sources:Amigo / QuickGO
Orthologs
	81608
	n/a
	ENSG00000145216
	n/a
	Q6UN15
	n/a
	NM_001134937; NM_001134938; NM_030917
	n/a
NP_001128409; NP_001128410; NP_112179; NP_001363673; NP_001363674;
	NP_001363675; NP_001363676; NP_001363677; NP_001363678; NP_001363679; NP_001363680; NP_001363681; NP_001363682; NP_001363683; NP_001363684; NP_001363685; NP_001363686; NP_001363687; NP_001363688; NP_001363689; NP_001363690; NP_001363691; NP_001363693; NP_001363694; NP_001363695; NP_001363696; NP_001363697; NP_001363698; NP_001363699; NP_001363700; NP_001363701; NP_001363702; NP_001363703; NP_001363704; NP_001363705; NP_001363706; NP_001363707; NP_001363708; NP_001363709; NP_001363710; NP_001363711; NP_001363712; NP_001363713; NP_001363714; NP_001363715
	n/a
	Wikidata
View/Edit Human

Factor interacting with PAPOLA and CPSF1 (i.e, FIP1L1; also termed Pre-mRNA 3'-end-processing factor FIP1) is a protein that in humans is encoded by the FIP1L1 gene (also known as Rhe, FIP1, and hFip1). A medically important aspect of the FIP1L1 gene is its fusion with other genes to form fusion genes which cause clonal hypereosinophilia and leukemic diseases in humans.

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