CPSF1

CPSF1
Identifiers
Aliases	CPSF1, CPSF160, HSU37012, P/cl.18, cleavage and polyadenylation specific factor 1
External IDs	OMIM: 606027 MGI: 2679722 HomoloGene: 40865 GeneCards: CPSF1
Gene location (Human)
Chr.	Chromosome 8 (human)
End	144,409,349 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	76,491,791 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; pituitary gland; ; anterior pituitary; ; duodenum; ; spleen; ; body of pancreas; ; right lobe of thyroid gland; ; body of stomach; ; prostate; ; left lobe of thyroid gland;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; hair follicle; ; primitive streak; ; adrenal gland; ; Paneth cell; ; interventricular septum; ; condyle; ; somite; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; enzyme binding; protein binding; mRNA 3'-UTR AU-rich region binding; RNA binding;
Cellular component	mRNA cleavage and polyadenylation specificity factor complex; nucleus; nucleoplasm;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA polyadenylation; mRNA processing; mRNA cleavage; mRNA 3'-end processing; mRNA export from nucleus; pre-mRNA cleavage required for polyadenylation; tRNA splicing, via endonucleolytic cleavage and ligation;
	Sources:Amigo / QuickGO
Orthologs
	29894
	94230
	ENSG00000071894
	ENSMUSG00000034022
	Q10570
	Q9EPU4
	NM_013291
	NM_001164173; NM_053193; NM_001361485
	NP_037423
	NP_001157645; NP_444423; NP_001348414
	Wikidata
View/Edit Human	View/Edit Mouse

Cleavage and polyadenylation specificity factor subunit 1 is a protein that in humans is encoded by the CPSF1 gene.

In most cases eukaryotic pre-messenger(m)RNA 3 prime ends are processed in two coordinated steps. First there is a site-specific cleavage by an endonuclease and then the addition of a poly(A) tail at the 3 prime end of the 5 prime cleavage product. Cleavage requires four multisubunit complexes, namely cleavage and polyadenylation specificity factor (CPSF), cleavage stimulation factor (CstF), cleavage factors Im and IIm (CFIm and CFIIm), along with a single subunit poly(A)polymerase (PAP). CPSF1 is the largest component of the CPSF complex composed of CPSF1, CPSF2, CPSF3, CPSF4, FIP1L1, Symplekin and WDR33 and located in the nucleus.

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