Enflurane

Enflurane (2-chloro-1,1,2-trifluoroethyl difluoromethyl ether) is a halogenated ether. Developed by Ross Terrell in 1963, it was first used clinically in 1966. It was increasingly used for inhalational anesthesia during the 1970s and 1980s but is no longer in common use.

Enflurane
Clinical data
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ATC code
Legal status
Legal status
  • BR: Class C1 (Other controlled substances)
Pharmacokinetic data
Protein binding97%
Identifiers
  • (RS)-2-chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.034.126
Chemical and physical data
FormulaC3H2ClF5O
Molar mass184.49 g·mol−1
3D model (JSmol)
SMILES
  • FC(Cl)C(F)(F)OC(F)F
  • InChI=1S/C3H2ClF5O/c4-1(5)3(8,9)10-2(6)7/h1-2H Y
  • Key:JPGQOUSTVILISH-UHFFFAOYSA-N Y
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Enflurane is a structural isomer of isoflurane. It vaporizes readily, but is a liquid at room temperature.

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