Emerin

EMD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JEI, 2ODC, 2ODG
Identifiers
Aliases	EMD, EDMD, LEMD5, STA, emerin
External IDs	OMIM: 300384 MGI: 108117 HomoloGene: 91 GeneCards: EMD
Gene location (Human)
Chr.	X chromosome (human)
End	154,381,574 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	73,305,154 bp
RNA expression pattern
	Top expressed in
	left uterine tube; ; popliteal artery; ; anterior pituitary; ; gastric mucosa; ; right coronary artery; ; canal of the cervix; ; ascending aorta; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; left coronary artery;
	Top expressed in
	yolk sac; ; lip; ; medial ganglionic eminence; ; ascending aorta; ; aortic valve; ; thymus; ; abdominal wall; ; esophagus; ; cumulus cell; ; hair follicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; beta-tubulin binding; actin binding; cadherin binding;
Cellular component	integral component of membrane; nuclear membrane; membrane; nuclear inner membrane; endoplasmic reticulum; microtubule; nuclear outer membrane; nucleus; nucleoplasm; cytoplasm; nuclear envelope; spindle pole centrosome; cortical endoplasmic reticulum; spindle;
Biological process	muscle contraction; regulation of canonical Wnt signaling pathway; cellular response to growth factor stimulus; muscle organ development; positive regulation of protein export from nucleus; mitotic nuclear membrane disassembly; skeletal muscle cell differentiation; mitotic nuclear membrane reassembly; negative regulation of fibroblast proliferation; negative regulation of canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2010
	13726
	ENSG00000102119
	ENSMUSG00000001964
	P50402
	O08579
	NM_000117
	NM_007927
	NP_000108
	NP_031953
	Wikidata
View/Edit Human	View/Edit Mouse

Emerin is a protein that in humans is encoded by the EMD gene, also known as the STA gene. Emerin, together with LEMD3, is a LEM domain-containing integral protein of the inner nuclear membrane in vertebrates. Emerin is highly expressed in cardiac and skeletal muscle. In cardiac muscle, emerin localizes to adherens junctions within intercalated discs where it appears to function in mechanotransduction of cellular strain and in beta-catenin signaling. Mutations in emerin cause X-linked recessive Emery–Dreifuss muscular dystrophy, cardiac conduction abnormalities and dilated cardiomyopathy.

It is named after Alan Emery.

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