ERAP1

ERAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YD0, 3MDJ, 3QNF, 3RJO
Identifiers
Aliases	ERAP1, A-LAP, ALAP, APPILS, ARTS-1, ARTS1, ERAAP, ERAAP1, PILS-AP, PILSAP, endoplasmic reticulum aminopeptidase 1
External IDs	OMIM: 606832 MGI: 1933403 HomoloGene: 140581 GeneCards: ERAP1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	96,808,100 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	74,841,320 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; rectum; ; monocyte; ; duodenum; ; bone marrow cells; ; Achilles tendon; ; bronchial epithelial cell; ; appendix; ; stromal cell of endometrium; ; thymus;
	Top expressed in
	duodenum; ; jejunum; ; thymus; ; ileum; ; liver; ; spleen; ; white adipose tissue; ; left lobe of liver; ; colon; ; seminal vesicula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	interleukin-6 receptor binding; peptide binding; zinc ion binding; metal ion binding; interleukin-1, type II receptor binding; peptidase activity; protein binding; aminopeptidase activity; metalloexopeptidase activity; hydrolase activity; metallopeptidase activity; endopeptidase activity; metalloaminopeptidase activity;
Cellular component	cytoplasm; integral component of membrane; cytosol; endoplasmic reticulum membrane; membrane; extracellular region; endoplasmic reticulum; extracellular exosome; extracellular space; endoplasmic reticulum lumen; plasma membrane;
Biological process	regulation of innate immune response; adaptive immune response; response to bacterium; immune system process; antigen processing and presentation of peptide antigen via MHC class I; proteolysis; positive regulation of angiogenesis; membrane protein ectodomain proteolysis; angiogenesis; fat cell differentiation; peptide catabolic process; antigen processing and presentation of endogenous peptide antigen via MHC class I; regulation of blood pressure; signal transduction; cell-cell signaling;
	Sources:Amigo / QuickGO
Orthologs
	51752
	80898
	ENSG00000164307
	ENSMUSG00000021583
	Q9NZ08
	Q9EQH2
	NM_001040458; NM_001198541; NM_016442; NM_001349244
	NM_030711
	NP_001035548; NP_001185470; NP_057526; NP_001336173
	NP_109636
	Wikidata
View/Edit Human	View/Edit Mouse

Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator, also known as endoplasmic reticulum aminopeptidase 1 (ARTS-1), is a protein which in humans is encoded by the ARTS-1 gene.

Endoplasmic reticulum amino peptidase 1 is active in the endoplasmic reticulum, which is involved in protein processing and transport. This protein is an aminopeptidase, which is an enzyme that cleaves peptides at the N-terminal into smaller fragments called amino acids.

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