ELK1

ELK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DUX
Identifiers
Aliases	ELK1, ETS transcription factor, ETS transcription factor ELK1
External IDs	OMIM: 311040 MGI: 101833 HomoloGene: 3832 GeneCards: ELK1
Gene location (Human)
Chr.	X chromosome (human)
End	47,650,604 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	20,816,847 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; thoracic diaphragm; ; vena cava; ; cardia; ; body of tongue; ; triceps brachii muscle; ; external globus pallidus; ; cerebellar vermis; ; pylorus; ; nucleus accumbens;
	Top expressed in
	ciliary body; ; substantia nigra; ; internal carotid artery; ; fossa; ; cerebellar vermis; ; Paneth cell; ; cumulus cell; ; retinal pigment epithelium; ; ventromedial nucleus; ; nucleus accumbens;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding; protein binding; double-stranded DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; axon terminus; nucleoplasm; neuronal cell body; dendrite; mitochondrion; nucleus;
Biological process	cell differentiation; regulation of transcription, DNA-templated; response to light stimulus; cellular response to testosterone stimulus; response to fibroblast growth factor; positive regulation of neuron death; transcription, DNA-templated; positive regulation of transcription, DNA-templated; cellular response to gamma radiation; cellular response to lipid; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	2002
	13712
	ENSG00000126767
	ENSMUSG00000009406
	P19419
	P41969
	NM_005229; NM_001114123; NM_001257168
	NM_007922
	NP_001107595; NP_001244097; NP_005220
	NP_031948
	Wikidata
View/Edit Human	View/Edit Mouse

ETS Like-1 protein Elk-1 is a protein that in humans is encoded by the ELK1. Elk-1 functions as a transcription activator. It is classified as a ternary complex factor (TCF), a subclass of the ETS family, which is characterized by a common protein domain that regulates DNA binding to target sequences. Elk1 plays important roles in various contexts, including long-term memory formation, drug addiction, Alzheimer's disease, Down syndrome, breast cancer, and depression.

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