Excitatory amino acid transporter 1

SLC1A3
Identifiers
Aliases	SLC1A3, EA6, EAAT1, GLAST, GLAST1, solute carrier family 1 member 3
External IDs	OMIM: 600111 MGI: 99917 HomoloGene: 20882 GeneCards: SLC1A3
Gene location (Human)
Chr.	Chromosome 5 (human)
End	36,688,334 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	8,740,248 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; external globus pallidus; ; Region I of hippocampus proper; ; inferior olivary nucleus; ; nucleus accumbens; ; middle temporal gyrus; ; optic nerve; ; amygdala; ; caudate nucleus; ; putamen;
	Top expressed in
	cerebellar vermis; ; paraventricular nucleus of hypothalamus; ; arcuate nucleus; ; globus pallidus; ; dorsomedial hypothalamic nucleus; ; lateral hypothalamus; ; ventromedial nucleus; ; median eminence; ; mammillary body; ; olfactory tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	amino acid binding; symporter activity; glutamate binding; L-glutamate transmembrane transporter activity; amino acid transmembrane transporter activity; high-affinity glutamate transmembrane transporter activity; acidic amino acid transmembrane transporter activity; glutamate:sodium symporter activity; metal ion binding;
Cellular component	integral component of membrane; cell projection; membrane; plasma membrane; cell surface; neuronal cell body; neuron projection; cell periphery; integral component of plasma membrane;
Biological process	chemical synaptic transmission; gamma-aminobutyric acid biosynthetic process; glutamate biosynthetic process; neuromuscular process controlling balance; response to light stimulus; cell morphogenesis involved in neuron differentiation; cranial nerve development; response to antibiotic; ion transport; sensory perception of sound; glutamate secretion; auditory behavior; neurotransmitter uptake; response to wounding; positive regulation of synaptic transmission; glutamate metabolic process; L-glutamate import; amino acid transport; D-aspartate import across plasma membrane; potassium ion transmembrane transport; L-glutamate import across plasma membrane; L-aspartate import across plasma membrane; chloride transmembrane transport; L-glutamate transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	6507
	20512
	ENSG00000079215
	ENSMUSG00000005360
	P43003
	P56564
	NM_001166695; NM_001166696; NM_001289939; NM_001289940; NM_004172
	NM_148938
	NP_001160167; NP_001160168; NP_001276868; NP_001276869; NP_004163
	NP_683740
	Wikidata
View/Edit Human	View/Edit Mouse

Excitatory amino acid transporter 1 (EAAT1) is a protein that, in humans, is encoded by the SLC1A3 gene. EAAT1 is also often called the GLutamate ASpartate Transporter 1 (GLAST-1).

EAAT1 is predominantly expressed in the plasma membrane, allowing it to remove glutamate from the extracellular space. It has also been localized in the inner mitochondrial membrane as part of the malate-aspartate shuttle.

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