Desmoglein-2

DSG2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YQG, 5ERD, 5J5J
Identifiers
Aliases	DSG2, ARVC10, ARVD10, CDHF5, CMD1BB, HDGC, desmoglein 2
External IDs	OMIM: 125671 MGI: 1196466 HomoloGene: 1464 GeneCards: DSG2
Gene location (Human)
Chr.	Chromosome 18 (human)
End	31,549,008 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	20,737,578 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; palpebral conjunctiva; ; parotid gland; ; hair follicle; ; rectum; ; lactiferous duct; ; duodenum; ; germinal epithelium; ; amniotic fluid; ; parietal pleura;
	Top expressed in
	left colon; ; parotid gland; ; epithelium of stomach; ; Paneth cell; ; crypt of lieberkuhn of small intestine; ; lacrimal gland; ; submandibular gland; ; pyloric antrum; ; mucous cell of stomach; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; metal ion binding; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication; cell adhesion molecule binding;
Cellular component	integral component of membrane; lateral plasma membrane; membrane; intercalated disc; cell-cell junction; plasma membrane; desmosome; cell surface; cell junction; apical plasma membrane; extracellular exosome; cornified envelope; intracellular membrane-bounded organelle;
Biological process	desmosome organization; maternal process involved in female pregnancy; response to progesterone; bundle of His cell-Purkinje myocyte adhesion involved in cell communication; cell adhesion; Purkinje myocyte development; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; homophilic cell adhesion via plasma membrane adhesion molecules; keratinization; cornification; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	1829
	13511
	ENSG00000046604
	ENSMUSG00000044393
	Q14126
	O55111
	NM_001943
	NM_007883
	NP_001934
	NP_031909
	Wikidata
View/Edit Human	View/Edit Mouse

Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene. Desmoglein-2 is highly expressed in epithelial cells and cardiomyocytes. Desmoglein-2 is localized to desmosome structures at regions of cell-cell contact and functions to structurally adhere adjacent cells together. In cardiac muscle, these regions are specialized regions known as intercalated discs. Mutations in desmoglein-2 have been associated with arrhythmogenic right ventricular cardiomyopathy and familial dilated cardiomyopathy.

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