DCP2

DCP2
Identifiers
Aliases	DCP2, NUDT20, decapping mRNA 2
External IDs	OMIM: 609844 MGI: 1917890 HomoloGene: 13968 GeneCards: DCP2
Gene location (Human)
Chr.	Chromosome 5 (human)
End	113,022,195 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	44,558,036 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; spongy bone; ; sperm; ; parietal pleura; ; placenta; ; monocyte; ; bone marrow; ; visceral pleura; ; endothelial cell;
	Top expressed in
	hand; ; otolith organ; ; utricle; ; primitive streak; ; superior cervical ganglion; ; vas deferens; ; condyle; ; abdominal wall; ; trigeminal ganglion; ; renal corpuscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	m7G(5')pppN diphosphatase activity; manganese ion binding; metal ion binding; protein binding; exoribonuclease activity, producing 5'-phosphomonoesters; RNA binding; hydrolase activity; 5'-3' exoribonuclease activity; telomerase RNA binding;
Cellular component	cytoplasm; RISC complex; cytosol; P-body; nucleoplasm; cell junction; nucleus; cytoplasmic ribonucleoprotein granule;
Biological process	mRNA catabolic process; regulation of mRNA stability; deadenylation-dependent decapping of nuclear-transcribed mRNA; exonucleolytic catabolism of deadenylated mRNA; histone mRNA catabolic process; RNA phosphodiester bond hydrolysis, exonucleolytic; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; negative regulation of telomere maintenance via telomerase; regulation of telomerase RNA localization to Cajal body;
	Sources:Amigo / QuickGO
Orthologs
	167227
	70640
	ENSG00000172795
	ENSMUSG00000024472
	Q8IU60
	Q9CYC6
	NM_001242377; NM_152624
	NM_027490
	NP_001229306; NP_689837
	NP_081766
	Wikidata
View/Edit Human	View/Edit Mouse

mRNA-decapping enzyme 2 is a protein that in humans is encoded by the DCP2 gene.

DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM]

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