Coxsackievirus and adenovirus receptor

CXADR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EAJ, 1F5W, 1JEW, 1KAC, 1P69, 1P6A, 1RSF, 2J12, 2J1K, 2NPL, 2W9L, 2WBW, 3J6L, 3J6M, 3J6N, 3J6O
Identifiers
Aliases	CXADR, CAR, CAR4/6, HCAR, coxsackie virus and adenovirus receptor, Ig-like cell adhesion molecule, CXADR Ig-like cell adhesion molecule
External IDs	OMIM: 602621 MGI: 1201679 HomoloGene: 1024 GeneCards: CXADR
Gene location (Human)
Chr.	Chromosome 21 (human)
End	17,593,579 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	78,156,662 bp
RNA expression pattern
	Top expressed in
	nipple; ; palpebral conjunctiva; ; vulva; ; pylorus; ; jejunal mucosa; ; human penis; ; gums; ; hair follicle; ; corpus epididymis; ; bronchial epithelial cell;
	Top expressed in
	ganglionic eminence; ; epithelium of stomach; ; left colon; ; medial ganglionic eminence; ; parotid gland; ; left lung lobe; ; atrioventricular valve; ; sexually immature organism; ; molar; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	PDZ domain binding; beta-catenin binding; connexin binding; virus receptor activity; integrin binding; protein binding; identical protein binding; signaling receptor binding; cell adhesion molecule binding; cell adhesive protein binding involved in AV node cell-bundle of His cell communication;
Cellular component	cytoplasm; integral component of membrane; cell body; membrane; intercalated disc; cell-cell junction; bicellular tight junction; filopodium; growth cone; adherens junction; neuromuscular junction; plasma membrane; integral component of plasma membrane; nucleoplasm; extracellular region; cell junction; apicolateral plasma membrane; basolateral plasma membrane; acrosomal vesicle; membrane raft; neuron projection; extracellular space; protein-containing complex;
Biological process	actin cytoskeleton reorganization; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell junction organization; epithelial structure maintenance; AV node cell to bundle of His cell communication; gamma-delta T cell activation; mitochondrion organization; neutrophil chemotaxis; transepithelial transport; homotypic cell-cell adhesion; heart development; cell adhesion; defense response to virus; regulation of immune response; viral entry into host cell; viral process; leukocyte migration; germ cell migration; AV node cell-bundle of His cell adhesion involved in cell communication; regulation of AV node cell action potential; negative regulation of cardiac muscle cell proliferation; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	1525
	13052
	ENSG00000154639
	ENSMUSG00000022865
	P78310
	P97792
	NM_001207063; NM_001207064; NM_001207065; NM_001207066; NM_001338
	NM_001025192; NM_001276263; NM_009988
	NP_001193992; NP_001193993; NP_001193994; NP_001193995; NP_001329
	NP_001020363; NP_001263192; NP_034118
	Wikidata
View/Edit Human	View/Edit Mouse

Coxsackievirus and adenovirus receptor (CAR) is a protein that in humans is encoded by the CXADR gene. The protein encoded by this gene is a type I membrane receptor for group B coxsackie viruses and subgroup C adenoviruses. CAR protein is expressed in several tissues, including heart, brain, and, more generally, epithelial and endothelial cells. In cardiac muscle, CAR is localized to intercalated disc structures, which electrically and mechanically couple adjacent cardiomyocytes. CAR plays an important role in the pathogenesis of myocarditis, dilated cardiomyopathy, and in arrhythmia susceptibility following myocardial infarction or myocardial ischemia. In addition, an isoform of CAR (CAR-SIV) has been recently identified in the cytoplasm of pancreatic beta cells. It's been suggested that CAR-SIV resides in the insulin secreting granules and might be involved in the virus infection of these cells.

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