Coxiella (bacterium)

Coxiella refers to a genus of Gram-negative bacteria in the family Coxiellaceae. It is named after Herald Rea Cox (1907–1986), an American bacteriologist. It is one of the Gammaproteobacteria.

Coxiella burnetii is the best known member of this genus. It is an intracellular parasite and it survives within the phagolysosomes of its host. It causes Q fever.

The majority of Coxiella’s described members are non pathogenic forms which are often found in ticks. Approximately two-thirds of tick species harbour Coxiella-like endosymbionts required for tick survival and reproduction. Genomes of Coxiella-like endosymbionts encode pathways for the biosynthesis of major B vitamins and co-factors that fit closely with the expected nutritional complements required for strict haematophagy. The experimental elimination of Coxiella-like endosymbionts typically results in decreased tick survival, molting, fecundity and egg viability, as well as in physical abnormalities. Coxiella-like endosymbionts are often misidentified as Coxiella burnetii; however, Coxiella-like endosymbionts lack virulence genes and cannot infect humans.