Clemmensen reduction
Clemmensen reduction is a chemical reaction described as a reduction of ketones or aldehydes to alkanes using zinc amalgam and concentrated hydrochloric acid (HCl). This reaction is named after Erik Christian Clemmensen, a Danish-American chemist.
| Clemmensen reduction | |||||||||||
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| Named after | Erik Christian Clemmensen | ||||||||||
| Reaction type | Organic redox reaction | ||||||||||
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| Catalyst | +Δ | ||||||||||
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| Organic Chemistry Portal | clemmensen-reduction | ||||||||||
| RSC ontology ID | RXNO:0000038 | ||||||||||
Clemmensen reduction conditions are particularly effective at reducing aryl-alkyl ketones, such as those formed in a Friedel-Crafts acylation. The two-step sequence of Friedel-Crafts acylation followed by Clemmensen reduction constitutes a classical strategy for the primary alkylation of arenes.
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