Claisen condensation

The Claisen condensation is a carbon–carbon bond forming reaction that occurs between two esters or one ester and another carbonyl compound in the presence of a strong base. The reaction produces a β-keto ester or a β-diketone. It is named after Rainer Ludwig Claisen, who first published his work on the reaction in 1887. The reaction has often been displaced by diketene-based chemistry, which affords acetoacetic esters.

Not to be confused with Claisen rearrangement or Claisen–Schmidt condensation.
Claisen condensation
Named after Rainer Ludwig Claisen
Reaction type Condensation reaction
Reaction
R-COO-R′
+
R-COO-R′ or Carbonyl
+
(Base: Na-OR')
↓
β-keto ester
+
R'-OH
Conditions
Typical solvents
R'-OH
Identifiers
Organic Chemistry Portal claisen-condensation
RSC ontology ID RXNO:0000043

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