Cayman Islands at the 2012 Summer Olympics

Cayman Islands competed at the 2012 Summer Olympics in London, United Kingdom from 27 July to 12 August 2012. This was the nation's ninth appearance at the Olympics, except the 1980 Summer Olympics in Moscow due to the United States-led boycott.

Five athletes from the Cayman Islands were selected to the team, participating only in athletics and swimming. Sprinter Kemar Hyman was the only athlete to compete at his first Olympics. Veteran sprinter Cydonie Mothersill, on the other hand, became the only female and the oldest athlete of the team, competing at her fifth Olympics. Swimmer Brett Fraser, and his brother Shaune advanced past the first round in the men's 100 m freestyle for the first time, since its swimming team began competing in 2004. Kemar Hyman carried the flag in the opening ceremony and Ronald Forbes was the flag bearer in the closing ceremony.