CYP2C19

CYP2C19
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4GQS
Identifiers
Aliases	CYP2C19, CPCJ, CYP2C, CYPIIC17, CYPIIC19, P450C2C, P450IIC19, cytochrome P450 family 2 subfamily C member 19
External IDs	OMIM: 124020 HomoloGene: 133565 GeneCards: CYP2C19
EC number	1.14.14.51
Gene location (Human)
Chr.	Chromosome 10 (human)
End	94,855,547 bp
RNA expression pattern
	Top expressed in
	liver; ; duodenum; ; right lobe of liver; ; gallbladder; ; gastric mucosa; ; body of stomach; ; vagina; ; fundus; ; skin of abdomen; ; thymus;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	iron ion binding; oxygen binding; arachidonic acid epoxygenase activity; metal ion binding; monooxygenase activity; steroid hydroxylase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; enzyme binding; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;
Cellular component	organelle membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum; cytoplasm;
Biological process	steroid metabolic process; epoxygenase P450 pathway; omega-hydroxylase P450 pathway; heterocycle metabolic process; monoterpenoid metabolic process; xenobiotic metabolic process; organic acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1557
	n/a
	ENSG00000165841
	n/a
	P33261
	n/a
	NM_000769
	n/a
	NP_000760
	n/a
	Wikidata
View/Edit Human

Cytochrome P450 2C19 (abbreviated CYP2C19) is an enzyme protein. It is a member of the CYP2C subfamily of the cytochrome P450 mixed-function oxidase system. This subfamily includes enzymes that catalyze metabolism of xenobiotics, including some proton pump inhibitors and antiepileptic drugs. In humans, it is the CYP2C19 gene that encodes the CYP2C19 protein. CYP2C19 is a liver enzyme that acts on at least 10% of drugs in current clinical use, most notably the antiplatelet treatment clopidogrel (Plavix), drugs that treat pain associated with ulcers, such as omeprazole, antiseizure drugs such as mephenytoin, the antimalarial proguanil, and the anxiolytic diazepam.

CYP2C19 has been annotated as (R)-limonene 6-monooxygenase and (S)-limonene 6-monooxygenase in UniProt.

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