CUL4B

CUL4B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DO7, 4A0C, 4A0L, 4A64
Identifiers
Aliases	CUL4B, CUL-4B, MRXHF2, MRXS15, MRXSC, SFM2, cullin 4B
External IDs	OMIM: 300304 MGI: 1919834 HomoloGene: 2660 GeneCards: CUL4B
Gene location (Human)
Chr.	X chromosome (human)
End	120,604,074 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	37,665,073 bp
RNA expression pattern
	Top expressed in
	sperm; ; corpus epididymis; ; caput epididymis; ; Achilles tendon; ; ganglionic eminence; ; stromal cell of endometrium; ; superficial temporal artery; ; anterior pituitary; ; seminal vesicula; ; tibia;
	Top expressed in
	secondary oocyte; ; seminiferous tubule; ; medullary collecting duct; ; spermatid; ; maxillary prominence; ; abdominal wall; ; aortic valve; ; supraoptic nucleus; ; yolk sac; ; somite;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	ubiquitin protein ligase activity; damaged DNA binding; protein binding; ubiquitin protein ligase binding;
Cellular component	cullin-RING ubiquitin ligase complex; nucleoplasm; extracellular exosome; nucleus; cytosol; Cul4B-RING E3 ubiquitin ligase complex; Cul4-RING E3 ubiquitin ligase complex; SCF ubiquitin ligase complex;
Biological process	positive regulation of protein catabolic process; nucleotide-excision repair, DNA damage recognition; ubiquitin-dependent protein catabolic process; histone H2A monoubiquitination; cellular response to DNA damage stimulus; positive regulation of G1/S transition of mitotic cell cycle; global genome nucleotide-excision repair; cell cycle; transcription-coupled nucleotide-excision repair; nucleotide-excision repair, DNA incision; neuron projection development; UV-damage excision repair; nucleotide-excision repair, preincision complex assembly; nucleotide-excision repair, DNA incision, 3'-to lesion; nucleotide-excision repair, DNA incision, 5'-to lesion; nucleotide-excision repair, DNA duplex unwinding; DNA repair; nucleotide-excision repair, preincision complex stabilization; post-translational protein modification; proteasomal protein catabolic process; protein ubiquitination; G1/S transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	8450
	72584
	ENSG00000158290
	ENSMUSG00000031095
	Q13620
	A2A432
	NM_001079872; NM_003588; NM_001330624; NM_001369145
	NM_001110142; NM_028288
	NP_001073341; NP_001317553; NP_003579; NP_001356074
	NP_001103612; NP_082564
	Wikidata
View/Edit Human	View/Edit Mouse

Cullin-4B is a protein that in humans is encoded by the CUL4B gene which is located on the X chromosome. CUL4B has high sequence similarity with CUL4A, with which it shares certain E3 ubiquitin ligase functions. CUL4B is largely expressed in the nucleus and regulates several key functions including: cell cycle progression, chromatin remodeling and neurological and placental development in mice. In humans, CUL4B has been implicated in X-linked intellectual disability and is frequently mutated in pancreatic adenocarcinomas and a small percentage of various lung cancers. Viruses such as HIV can also co-opt CUL4B-based complexes to promote viral pathogenesis. CUL4B complexes containing Cereblon are also targeted by the teratogenic drug thalidomide.

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