Cereblon

CRBN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4M91, 4TZ4, 5FQD, 5HXB
Identifiers
Aliases	CRBN, MRT2, MRT2A, Cereblon
External IDs	OMIM: 609262 MGI: 1913277 HomoloGene: 9461 GeneCards: CRBN
Gene location (Human)
Chr.	Chromosome 3 (human)
End	3,179,727 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	106,777,038 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; Brodmann area 23; ; biceps brachii; ; endothelial cell; ; superficial temporal artery; ; middle temporal gyrus; ; corpus callosum; ; postcentral gyrus; ; parietal pleura; ; superior frontal gyrus;
	Top expressed in
	pontine nuclei; ; spermatocyte; ; medial vestibular nucleus; ; medial dorsal nucleus; ; dorsal tegmental nucleus; ; ventral tegmental area; ; Region I of hippocampus proper; ; mammillary body; ; facial motor nucleus; ; lateral hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; metal ion binding;
Cellular component	cytoplasm; Cul4A-RING E3 ubiquitin ligase complex; nucleolus; membrane; nucleus;
Biological process	negative regulation of protein homooligomerization; positive regulation of protein homodimerization activity; protein ubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; negative regulation of ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	51185
	58799
	ENSG00000113851
	ENSMUSG00000005362
	Q96SW2
	Q8C7D2
	NM_001173482; NM_016302
	NM_021449; NM_175357
	NP_001166953; NP_057386
	NP_067424; NP_780566
	Wikidata
View/Edit Human	View/Edit Mouse

Cereblon is a protein that in humans is encoded by the CRBN gene. The gene that encodes the cereblon protein is found on the human chromosome 3, on the short arm at position p26.3 from base pair 3,190,676 to base pair 3,221,394. CRBN orthologs are highly conserved from plants to humans.

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