CDX1

CDX1
Identifiers
Aliases	CDX1, caudal type homeobox 1, Homeobox protein CDX-1
External IDs	OMIM: 600746 MGI: 88360 HomoloGene: 1366 GeneCards: CDX1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	150,184,558 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	61,169,271 bp
RNA expression pattern
	Top expressed in
	rectum; ; duodenum; ; jejunal mucosa; ; appendix; ; stromal cell of endometrium; ; smooth muscle tissue; ; lymph node; ; placenta; ; breast; ; face;
	Top expressed in
	left colon; ; crypt of lieberkuhn of small intestine; ; ileum; ; primitive streak; ; duodenum; ; Paneth cell; ; jejunum; ; Hindgut; ; mesoderm; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; methyl-CpG binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cellular component	nucleus;
Biological process	animal organ morphogenesis; multicellular organism development; pattern specification process; bone morphogenesis; cell differentiation; anterior/posterior axis specification; regulation of transcription, DNA-templated; regulation of somitogenesis; positive regulation of transcription by RNA polymerase II; anterior/posterior pattern specification; transcription by RNA polymerase II; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	1044
	12590
	ENSG00000113722
	ENSMUSG00000024619
	P47902
	P18111
	NM_001804
	NM_009880
	NP_001795
	NP_034010
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein CDX-1 is a protein in humans that is encoded by the CDX1 gene. CDX1 is expressed in the developing endoderm and its expression persists in the intestine throughout adulthood. CDX1 protein expression varies along the intestine, with high expression in intestinal crypts and diminishing expression along intestinal villi.

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