Integrin beta 1

ITGB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4WK4, 3G9W, 3T9K, 3VI3, 3VI4, 4DX9, 4WJK, 4WK0, 4WK2
Identifiers
Aliases	ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB, integrin subunit beta 1
External IDs	OMIM: 135630 MGI: 96610 HomoloGene: 22999 GeneCards: ITGB1
Gene location (Human)
Chr.	Chromosome 10 (human)
End	33,005,792 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	129,459,681 bp
RNA expression pattern
	Top expressed in
	visceral pleura; ; seminal vesicula; ; parietal pleura; ; stromal cell of endometrium; ; tibia; ; smooth muscle tissue; ; superficial temporal artery; ; palpebral conjunctiva; ; right ventricle; ; ascending aorta;
	Top expressed in
	left lung lobe; ; belly cord; ; atrium; ; uterus; ; calvaria; ; extraocular muscle; ; molar; ; interventricular septum; ; ankle joint; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	virus receptor activity; metal ion binding; integrin binding; protein binding; laminin binding; cell adhesion molecule binding; collagen binding involved in cell-matrix adhesion; coreceptor activity; protease binding; fibronectin binding; actin binding; C-X3-C chemokine binding; protein heterodimerization activity; protein-containing complex binding; cadherin binding; signaling receptor activity;
Cellular component	cytoplasm; endosome; membrane; melanosome; ruffle; integrin alpha8-beta1 complex; synapse; ruffle membrane; integrin complex; perinuclear region of cytoplasm; cell projection; dendritic spine; cell surface; cleavage furrow; integrin alpha7-beta1 complex; extracellular exosome; lamellipodium; integral component of membrane; recycling endosome; integrin alpha1-beta1 complex; intercalated disc; filopodium; neuromuscular junction; receptor complex; plasma membrane; integrin alpha11-beta1 complex; myelin sheath abaxonal region; synaptic membrane; integrin alpha10-beta1 complex; cell junction; integrin alpha2-beta1 complex; sarcolemma; external side of plasma membrane; cytoplasmic vesicle; integrin alpha3-beta1 complex; membrane raft; focal adhesion; glial cell projection; Schaffer collateral - CA1 synapse; glutamatergic synapse; integral component of synaptic membrane; protein-containing complex;
Biological process	leukocyte cell-cell adhesion; cell migration involved in sprouting angiogenesis; stress fiber assembly; viral entry into host cell; B cell differentiation; neuron projection development; transforming growth factor beta receptor signaling pathway; regulation of collagen catabolic process; negative regulation of cell differentiation; cardiac muscle cell differentiation; cellular response to low-density lipoprotein particle stimulus; in utero embryonic development; cell-substrate adhesion; positive regulation of GTPase activity; regulation of immune response; viral process; dendrite morphogenesis; cell fate specification; G1 phase; heterotypic cell-cell adhesion; extracellular matrix organization; cell-cell adhesion mediated by integrin; cellular defense response; cell adhesion; formation of radial glial scaffolds; axon extension; leukocyte tethering or rolling; integrin-mediated signaling pathway; cell-matrix adhesion; sarcomere organization; negative regulation of anoikis; leukocyte migration; homophilic cell adhesion via plasma membrane adhesion molecules; visual learning; calcium-independent cell-matrix adhesion; cardiac muscle tissue development; negative regulation of Rho protein signal transduction; receptor internalization; regulation of cell cycle; positive regulation of cell population proliferation; positive regulation of apoptotic process; mesodermal cell differentiation; cell migration; germ cell migration; cell adhesion mediated by integrin; basement membrane organization; positive regulation of protein localization to plasma membrane; G1/S transition of mitotic cell cycle; phagocytosis; cytokine-mediated signaling pathway; cell projection organization; lamellipodium assembly; positive regulation of angiogenesis; modulation of chemical synaptic transmission; positive regulation of protein kinase B signaling; positive regulation of signaling receptor activity; positive regulation of cell migration;
	Sources:Amigo / QuickGO
Orthologs
	3688
	16412
	ENSG00000150093
	ENSMUSG00000025809
	P05556
	P09055
NM_002211; NM_033666; NM_033667; NM_033668; NM_033669;
	NM_133376
	NM_010578
	NP_002202; NP_391988; NP_596867
	NP_034708
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor that in humans is encoded by the ITGB1 gene. This integrin associates with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrin alpha 3 to form integrin receptors for netrin 1 and reelin. These and other integrin beta 1 complexes have been historically known as very late activation (VLA) antigens.

Integrin beta 1 is expressed as at least four different isoforms. In cardiac muscle and skeletal muscle, the integrin beta-1D isoform is specifically expressed, and localizes to costameres, where it aids in the lateral force transmission from the Z-discs to the extracellular matrix. Abnormal levels of integrin beta-1D have been found in limb girdle muscular dystrophy and polyneuropathy.

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