IL2RA

IL2RA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z92, 2B5I, 2ERJ, 3IU3, 3NFP
Identifiers
Aliases	IL2RA, CD25, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha
External IDs	OMIM: 147730 MGI: 96549 HomoloGene: 360 GeneCards: IL2RA
Gene location (Human)
Chr.	Chromosome 10 (human)
End	6,062,370 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	11,698,004 bp
RNA expression pattern
	Top expressed in
	lymph node; ; appendix; ; spleen; ; gallbladder; ; blood; ; smooth muscle tissue; ; thymus; ; rectum; ; ascending aorta; ; upper lobe of left lung;
	Top expressed in
	thymus; ; secondary oocyte; ; lymph node; ; blood; ; sternocleidomastoid muscle; ; esophagus; ; lip; ; muscle tissue; ; skeletal muscle tissue; ; spleen;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	interleukin-2 receptor activity; interleukin-2 binding; protein binding;
Cellular component	integral component of membrane; membrane; plasma membrane; cell surface; external side of plasma membrane; intracellular anatomical structure; interleukin-2 receptor complex;
Biological process	Notch signaling pathway; positive regulation of T cell differentiation; regulation of T cell tolerance induction; inflammatory response to antigenic stimulus; negative regulation of defense response to virus; immune system process; activation-induced cell death of T cells; negative regulation of lymphocyte proliferation; MAPK cascade; T cell homeostasis; regulation of T cell homeostatic proliferation; cell surface receptor signaling pathway; negative regulation of T cell proliferation; negative regulation of immune response; immune response; positive regulation of T cell proliferation; cell population proliferation; inflammatory response; negative regulation of inflammatory response; positive regulation of activated T cell proliferation; apoptotic process; regulation of regulatory T cell differentiation; cytokine-mediated signaling pathway; interleukin-2-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3559
	16184
	ENSG00000134460
	ENSMUSG00000026770
	P01589
	P01590
	NM_000417; NM_001308242; NM_001308243
	NM_008367
	NP_000408; NP_001295171; NP_001295172
	NP_032393
	Wikidata
View/Edit Human	View/Edit Mouse

The Interleukin-2 receptor alpha chain (also called TAC antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity Interleukin-2 receptor, consisting of alpha (IL2RA), beta (IL2RB) and the common gamma chain (IL2RG). As the name indicates, this receptor interacts with Interleukin-2, a pleiotropic cytokine which plays an important role in immune homeostasis.

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