Complement component 1r

C1R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1APQ, 1GPZ, 1MD7, 1MD8, 2QY0
Identifiers
Aliases	C1R, complement C1r, EDSPD1
External IDs	OMIM: 613785 MGI: 3779804 HomoloGene: 1313 GeneCards: C1R
Gene location (Human)
Chr.	Chromosome 12 (human)
End	7,092,540 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	124,558,130 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; gallbladder; ; right coronary artery; ; gastric mucosa; ; left uterine tube; ; left coronary artery; ; urinary bladder; ; canal of the cervix; ; tibial nerve; ; myometrium;
	Top expressed in
	white adipose tissue; ; adrenal gland; ; urinary bladder; ; liver; ; ovary; ; skeletal muscle tissue; ; spleen; ; islet of Langerhans; ; lung; ; testicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; serine-type endopeptidase activity; protein binding; hydrolase activity; calcium ion binding;
Cellular component	extracellular region; blood microparticle; extracellular exosome; extracellular space;
Biological process	immune response; proteolysis; complement activation, classical pathway; immune system process; innate immune response; complement activation; regulation of complement activation; zymogen activation;
	Sources:Amigo / QuickGO
Orthologs
	715
	667277
	ENSG00000159403; ENSG00000288512
	ENSMUSG00000098470
	P00736
	Q8CFG9
	NM_001733; NM_001354346
	NM_001113356
	NP_001724; NP_001341275
	NP_001106827
	Wikidata
View/Edit Human	View/Edit Mouse

Complement C1r subcomponent (EC 3.4.21.41, activated complement C1r, C overbar 1r esterase, C1r) is a protein involved in the complement system of the innate immune system. In humans, C1r is encoded by the C1R gene.

C1r along with C1q and C1s form the C1 complex, which is the first component of the serum complement system. C1r is an enzyme that activates C1s to its active form, by proteolytic cleavage.

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