Complement component 1s

C1S
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ELV, 1NZI, 4J1Y, 4LMF, 4LOR, 4LOS, 4LOT
Identifiers
Aliases	C1S, EDSPD2, complement C1s
External IDs	OMIM: 120580 MGI: 3644269 HomoloGene: 1314 GeneCards: C1S
EC number	3.4.21.42
Gene location (Human)
Chr.	Chromosome 12 (human)
End	7,071,032 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	124,613,044 bp
RNA expression pattern
	Top expressed in
	pericardium; ; right lobe of liver; ; parietal pleura; ; gallbladder; ; gastric mucosa; ; tibial nerve; ; left uterine tube; ; synovial joint; ; canal of the cervix; ; right coronary artery;
	Top expressed in
	morula; ; white adipose tissue; ; bone marrow; ; adrenal gland; ; urinary bladder; ; ovary; ; lens; ; islet of Langerhans; ; superior frontal gyrus; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; peptidase activity; serine-type peptidase activity; protein binding; hydrolase activity; metal ion binding; identical protein binding; serine-type endopeptidase activity;
Cellular component	blood microparticle; extracellular exosome; extracellular region; extracellular space;
Biological process	proteolysis; complement activation, classical pathway; immune system process; innate immune response; complement activation, lectin pathway; complement activation; regulation of complement activation;
	Sources:Amigo / QuickGO
Orthologs
	716
	317677
	ENSG00000182326
	ENSMUSG00000079343
	P09871
	Q8CFG8
	NM_001734; NM_201442; NM_001346850
	NM_173864
	NP_001333779; NP_001725; NP_958850
	NP_776289
	Wikidata
View/Edit Human	View/Edit Mouse

Complement component 1s (EC 3.4.21.42, C1 esterase, activated complement C1s, complement C overbar 1r, C1s) is a protein involved in the complement system. C1s is part of the C1 complex. In humans, it is encoded by the C1S gene.

C1s cleaves C4 and C2, which eventually leads to the production of the classical pathway C3-convertase.

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