Busulfan

Busulfan
Clinical data
Trade names	Myleran, Busilvex, Busulfex IV
Other names	1,4-butanediol dimethanesulfonate
AHFS/Drugs.com	Monograph
MedlinePlus	a682248
License data	EU EMA: by INN; US DailyMed: Busulfan; US FDA: Busulfan;
Pregnancy; category	AU: D;
Routes of; administration	By mouth, intravenous
ATC code	L01AB01 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: WARNINGRx-only; EU: Rx-only;
Pharmacokinetic data
Bioavailability	60–80% (oral)
Protein binding	32.4%
Metabolism	Liver
Elimination half-life	2.5 hours
Excretion	Urine (25–60%)
Identifiers
	IUPAC name Butane-1,4-diyl dimethanesulfonate;
CAS Number	55-98-1 ;
PubChem CID	2478;
IUPHAR/BPS	7136;
DrugBank	DB01008 ;
ChemSpider	2384 ;
UNII	G1LN9045DK;
KEGG	D00248 ;
ChEBI	CHEBI:28901 ;
ChEMBL	ChEMBL820 ;
CompTox Dashboard (EPA)	DTXSID3020910 ;
ECHA InfoCard	100.000.228
Chemical and physical data
Formula	C6H14O6S2
Molar mass	246.29 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CS(=O)(=O)OCCCCOS(=O)(=O)C;
	InChI InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3 ; Key:COVZYZSDYWQREU-UHFFFAOYSA-N ;
	(verify)

Busulfan (Myleran, GlaxoSmithKline, Busulfex IV, Otsuka America Pharmaceutical, Inc.) is a chemotherapy drug in use since 1959. It is a cell cycle non-specific alkylating antineoplastic agent, in the class of alkyl sulfonates. Its chemical designation is 1,4-butanediol dimethanesulfonate.

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