Amlodipine/benazepril

Amlodipine/benazepril
Combination of
Amlodipine	Calcium channel blocker
Benazepril	ACE inhibitor
Clinical data
Trade names	Lotrel
AHFS/Drugs.com	Professional Drug Facts
License data	US DailyMed: Amlodipine and benazepril;
Routes of; administration	By mouth
ATC code	C09BB13 (WHO) ;
Legal status
Legal status	US: ℞-only;
Identifiers
CAS Number	357437-90-2 ;
PubChem CID	5746247;
ChemSpider	4676979 ;
KEGG	D11069;
CompTox Dashboard (EPA)	DTXSID20189285 ;
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Amlodipine/benazepril, sold under the brand name Lotrel among others, is a fixed-dose combination medication used to treat high blood pressure. It is a combination of amlodipine, as the besilate, a calcium channel blocker, and benazepril, an angiotensin converting enzyme inhibitor. It may be used if a single agent is not sufficient. It is taken by mouth.

Common side effects include cough, dizziness, and swelling. Serious side effects may include angioedema, myocardial infarction, high blood potassium, liver problems, and low blood pressure. Use in pregnancy is not recommended. Amlodipine works by increasing the size of arteries while benazepril works by decreasing renin-angiotensin-aldosterone system activity.

The combination was approved for medical use in the United States in 1995. It is available as a generic medication. In 2021, it was the 150th most commonly prescribed medication in the United States, with more than 3 million prescriptions.

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