Benazepril

Benazepril
Clinical data
Pronunciation	/bəˈnæzəprɪl/
Trade names	Lotensin, others
AHFS/Drugs.com	Monograph
MedlinePlus	a692011
License data	US DailyMed: Benazepril;
Routes of; administration	By mouth
ATC code	C09AA07 (WHO) ;
Legal status
Legal status	US: ℞-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Protein binding	96.7%
Metabolism	Liver glucuronidation
Elimination half-life	10-11 hours
Excretion	Kidney and bile duct
Identifiers
	IUPAC name 2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid;
CAS Number	86541-75-5 ;
PubChem CID	5362124;
IUPHAR/BPS	6374;
DrugBank	DB00542 ;
ChemSpider	4514935 ;
UNII	UDM7Q7QWP8;
KEGG	D07499; D00620;
ChEBI	CHEBI:3011 ;
ChEMBL	ChEMBL838 ;
CompTox Dashboard (EPA)	DTXSID5022645 ;
Chemical and physical data
Formula	C24H28N2O5
Molar mass	424.497 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC)[C@@H](N[C@@H]2C(=O)N(c1ccccc1CC2)CC(=O)O)CCc3ccccc3;
	InChI InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1 ; Key:XPCFTKFZXHTYIP-PMACEKPBSA-N ;
	(verify)

Benazepril, sold under the brand name Lotensin among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. It is a reasonable initial treatment for high blood pressure. It is taken by mouth. Versions are available as the combinations benazepril/hydrochlorothiazide and benazepril/amlodipine.

Common side effects include feeling tired, dizziness, cough, and light-headedness with standing. Serious side effects may include kidney problems, low blood pressure, high blood potassium, and angioedema. Use in pregnancy may harm the baby, while use when breastfeeding may be safe. It is an ACE inhibitor and works by decreasing renin-angiotensin-aldosterone system activity.

Benazepril was patented in 1981 and came into medical use in 1990. It is available as a generic medication. In 2021, it was the 147th most commonly prescribed medication in the United States, with more than 3 million prescriptions.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.