Arginase
Arginase (EC 3.5.3.1, arginine amidinase, canavanase, L-arginase, arginine transamidinase) is a manganese-containing enzyme. The reaction catalyzed by this enzyme is:
- arginine + H2O → ornithine + urea
| Arginase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Ribbon diagram of human arginase I trimer. PDB entry 2pha | |||||||||
| Identifiers | |||||||||
| EC no. | 3.5.3.1 | ||||||||
| CAS no. | 9000-96-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| Liver arginase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ARG1 | ||||||
| NCBI gene | 383 | ||||||
| HGNC | 663 | ||||||
| OMIM | 608313 | ||||||
| RefSeq | NM_000045 | ||||||
| UniProt | P05089 | ||||||
| Other data | |||||||
| EC number | 3.5.3.1 | ||||||
| Locus | Chr. 6 q23 | ||||||
| |||||||
| Arginase, type II | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ARG2 | ||||||
| NCBI gene | 384 | ||||||
| HGNC | 664 | ||||||
| OMIM | 107830 | ||||||
| RefSeq | NM_001172 | ||||||
| UniProt | P78540 | ||||||
| Other data | |||||||
| EC number | 3.5.3.1 | ||||||
| Locus | Chr. 14 q24.1 | ||||||
| |||||||
It is the final enzyme of the urea cycle. It is ubiquitous to all domains of life.
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