ARG2

ARG2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PQ3, 4HZE, 4I06, 4IE2, 4IE3, 4IXU, 4IXV
Identifiers
Aliases	ARG2, arginase 2
External IDs	OMIM: 107830 MGI: 1330806 HomoloGene: 906 GeneCards: ARG2
Gene location (Human)
Chr.	Chromosome 14 (human)
End	67,651,708 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	79,203,075 bp
RNA expression pattern
	Top expressed in
	oocyte; ; renal medulla; ; kidney; ; secondary oocyte; ; islet of Langerhans; ; pituitary gland; ; anterior pituitary; ; prostate; ; kidney tubule; ; left lobe of thyroid gland;
	Top expressed in
	duodenum; ; jejunum; ; hair follicle; ; secondary oocyte; ; intestinal villus; ; spermatid; ; utricle; ; saccule; ; blood; ; lacrimal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines; arginase activity; hydrolase activity; metal ion binding; manganese ion binding;
Cellular component	mitochondrial matrix; mitochondrion; cytoplasm;
Biological process	urea cycle; ureteric bud development; nitric oxide biosynthetic process; striated muscle contraction; arginine metabolic process; negative regulation of type 2 immune response; negative regulation of tumor necrosis factor production; negative regulation of macrophage inflammatory protein 1 alpha production; negative regulation of chemokine (C-C motif) ligand 4 production; negative regulation of chemokine (C-C motif) ligand 5 production; negative regulation of defense response to bacterium; regulation of reactive oxygen species biosynthetic process; negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process; negative regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of cellular senescence; adaptive immune response; immune system process; innate immune response; arginine catabolic process to ornithine;
	Sources:Amigo / QuickGO
Orthologs
	384
	11847
	ENSG00000081181
	ENSMUSG00000021125
	P78540
	O08691
	NM_001172
	NM_009705
	NP_001163
	NP_033835
	Wikidata
View/Edit Human	View/Edit Mouse

Arginase, type II is an arginase protein that in humans is encoded by the ARG2 gene.

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