Aldehyde oxidase
Aldehyde oxidase (AO) is a metabolizing enzyme, located in the cytosolic compartment of tissues in many organisms. AO catalyzes the oxidation of aldehydes into carboxylic acid, and in addition, catalyzes the hydroxylation of some heterocycles. It can also catalyze the oxidation of both cytochrome P450 and monoamine oxidase (MAO) intermediate products. AO plays an important role in the metabolism of several drugs.
| Aldehyde oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Model of human aldehyde oxidase after PDB: 4UHW. | |||||||||
| Identifiers | |||||||||
| EC no. | 1.2.3.1 | ||||||||
| CAS no. | 9029-07-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| aldehyde oxidase 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | AOX1 | ||||||
| NCBI gene | 316 | ||||||
| HGNC | 553 | ||||||
| OMIM | 602841 | ||||||
| RefSeq | NM_001159 | ||||||
| UniProt | Q06278 | ||||||
| Other data | |||||||
| EC number | 1.2.3.1 | ||||||
| Locus | Chr. 2 q33 | ||||||
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