Aldehyde oxidase 1

AOX1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UHW, 4UHX, 5EPG
Identifiers
Aliases	AOX1, AO, AOH1, aldehyde oxidase 1
External IDs	OMIM: 602841 MGI: 88035 HomoloGene: 68165 GeneCards: AOX1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	200,677,064 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	58,145,572 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; body of pancreas; ; left uterine tube; ; germinal epithelium; ; subcutaneous adipose tissue; ; kidney tubule; ; gastric mucosa; ; kidney; ; popliteal artery; ; parietal pleura;
	Top expressed in
	left lobe of liver; ; brown adipose tissue; ; soleus muscle; ; white adipose tissue; ; facial motor nucleus; ; esophagus; ; intercostal muscle; ; subcutaneous adipose tissue; ; right lung; ; extraocular muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity, acting on CH-OH group of donors; iron-sulfur cluster binding; NAD binding; metal ion binding; catalytic activity; electron transfer activity; oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors; aldehyde oxidase activity; iron ion binding; protein homodimerization activity; molybdopterin cofactor binding; flavin adenine dinucleotide binding; 2 iron, 2 sulfur cluster binding; identical protein binding; xanthine dehydrogenase activity; FAD binding;
Cellular component	extracellular exosome; cytoplasm; cytosol; nuclear body;
Biological process	xanthine catabolic process; vitamin B6 metabolic process; electron transport chain;
	Sources:Amigo / QuickGO
Orthologs
	316
	11761
	ENSG00000138356
	ENSMUSG00000063558
	Q06278
	O54754
	NM_001159
	NM_009676
	NP_001150
	NP_033806
	Wikidata
View/Edit Human	View/Edit Mouse

Aldehyde oxidase 1 is an enzyme that in humans is encoded by the AOX1 gene.

Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide.

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