Adenomatous polyposis coli

APC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DEB, 1EMU, 1JPP, 1M5I, 1T08, 1TH1, 1V18, 2RQU, 3AU3, 3NMW, 3NMX, 3NMZ, 3QHE, 3RL7, 3RL8, 3T7U, 4G69, 4YJL, 4YK6, 4YJE
Identifiers
Aliases	APC, BTPS2, DP2, DP2.5, DP3, GS, PPP1R46, adenomatous polyposis coli, WNT signaling pathway regulator, Genes
External IDs	OMIM: 611731 MGI: 88039 HomoloGene: 30950 GeneCards: APC
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	34,322,552 bp
RNA expression pattern
	n/a
	Top expressed in
	olfactory bulb; ; substantia nigra; ; lateral geniculate nucleus; ; pontine nuclei; ; medial dorsal nucleus; ; subiculum; ; medial geniculate nucleus; ; anterior horn of spinal cord; ; prefrontal cortex; ; fossa;
	More reference expression data
Gene ontology
Molecular function	gamma-catenin binding; protein kinase binding; microtubule plus-end binding; microtubule binding; cadherin binding; protein kinase regulator activity; protein binding; beta-catenin binding; ubiquitin protein ligase binding; identical protein binding; dynein complex binding;
Cellular component	cytoskeleton; adherens junction; beta-catenin destruction complex; nucleoplasm; cytoplasm; cell projection; cytosol; catenin complex; cell junction; nucleus; lamellipodium; membrane; Wnt signalosome; centrosome; kinetochore; bicellular tight junction; ruffle membrane; plasma membrane; lateral plasma membrane; perinuclear region of cytoplasm; microtubule; cytoplasmic microtubule;
Biological process	negative regulation of cell population proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; mitotic spindle assembly checkpoint signaling; positive regulation of cell migration; positive regulation of protein catabolic process; bicellular tight junction assembly; regulation of microtubule-based process; positive regulation of pseudopodium assembly; regulation of attachment of spindle microtubules to kinetochore; cellular response to DNA damage stimulus; negative regulation of Wnt signaling pathway; cell adhesion; mitotic cytokinesis; negative regulation of microtubule depolymerization; positive regulation of apoptotic process; canonical Wnt signaling pathway; cell migration; beta-catenin destruction complex assembly; beta-catenin destruction complex disassembly; negative regulation of canonical Wnt signaling pathway; Wnt signaling pathway; protein deubiquitination; insulin receptor signaling pathway; positive regulation of cell death; protein homooligomerization; positive regulation of protein localization to centrosome; protein-containing complex assembly; cell fate specification; pattern specification process; regulation of cell differentiation; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	324
	11789
	ENSG00000134982
	ENSMUSG00000005871
	P25054
	Q61315
	NM_001127511; NM_000038; NM_001127510
	NM_007462; NM_001360979; NM_001360980
NP_000029; NP_001120982; NP_001120983; NP_001341824; NP_001341825;
	NP_001341826; NP_001341827; NP_001341828; NP_001341829; NP_001341830; NP_001341831; NP_001341832; NP_001341833; NP_001341834; NP_001341835
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Adenomatous polyposis coli (APC) also known as deleted in polyposis 2.5 (DP2.5) is a protein that in humans is encoded by the APC gene. The APC protein is a negative regulator that controls beta-catenin concentrations and interacts with E-cadherin, which are involved in cell adhesion. Mutations in the APC gene may result in colorectal cancer and desmoid tumors.

APC is classified as a tumor suppressor gene. Tumor suppressor genes prevent the uncontrolled growth of cells that may result in cancerous tumors. The protein made by the APC gene plays a critical role in several cellular processes that determine whether a cell may develop into a tumor. The APC protein helps control how often a cell divides, how it attaches to other cells within a tissue, how the cell polarizes and the morphogenesis of the 3D structures, or whether a cell moves within or away from tissue. This protein also helps ensure that the chromosome number in cells produced through cell division is correct. The APC protein accomplishes these tasks mainly through association with other proteins, especially those that are involved in cell attachment and signaling. The activity of one protein in particular, beta-catenin, is controlled by the APC protein (see: Wnt signaling pathway). Regulation of beta-catenin prevents genes that stimulate cell division from being turned on too often and prevents cell overgrowth.

The human APC gene is located on the long (q) arm of chromosome 5 in band q22.2 (5q22.2). The APC gene has been shown to contain an internal ribosome entry site. APC orthologs have also been identified in all mammals for which complete genome data are available.

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