ADCY2

ADCY2
Identifiers
Aliases	ADCY2, AC2, HBAC2, adenylate cyclase 2 (brain), adenylate cyclase 2
External IDs	OMIM: 103071 MGI: 99676 HomoloGene: 75133 GeneCards: ADCY2
Gene location (Human)
Chr.	Chromosome 5 (human)
End	7,830,081 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	69,147,660 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; entorhinal cortex; ; postcentral gyrus; ; biceps brachii; ; deltoid muscle; ; endothelial cell; ; superior frontal gyrus; ; thoracic diaphragm; ; Brodmann area 46;
	Top expressed in
	primary motor cortex; ; cingulate gyrus; ; digastric muscle; ; Region I of hippocampus proper; ; temporal muscle; ; superior frontal gyrus; ; extraocular muscle; ; sternocleidomastoid muscle; ; dentate gyrus; ; substantia nigra;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; manganese ion binding; adenylate cyclase binding; metal ion binding; lyase activity; protein heterodimerization activity; phosphorus-oxygen lyase activity; ATP binding; magnesium ion binding; guanylate cyclase activity; adenylate cyclase activity;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; intracellular anatomical structure; dendrite; membrane raft; guanylate cyclase complex, soluble;
Biological process	intracellular signal transduction; cellular response to forskolin; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cellular response to glucagon stimulus; cyclic nucleotide biosynthetic process; renal water homeostasis; cAMP biosynthetic process; cGMP biosynthetic process; signal transduction; adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; cAMP-mediated signaling; G protein-coupled receptor signaling pathway; activation of adenylate cyclase activity; activation of protein kinase A activity;
	Sources:Amigo / QuickGO
Orthologs
	108
	210044
	ENSG00000078295
	ENSMUSG00000021536
	Q08462
	Q80TL1; Q3V1Q3
	NM_020546
	NM_153534
	NP_065433
	NP_705762
	Wikidata
View/Edit Human	View/Edit Mouse

Adenylyl cyclase type 2 is an enzyme typically expressed in the brain of humans, that is encoded by the ADCY2 gene. It belongs to the adenylyl cyclase class-3 or guanylyl cyclase family because it contains two guanylate cyclase domains. ADCY2 is one of ten different mammalian isoforms of adenylyl cyclases. ADCY2 can be found on chromosome 5 and the "MIR2113-POU3F2" region of chromosome 6, with a length of 1091 amino-acids. An essential cofactor for ADCY2 is magnesium; two ions bind per subunit.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.