4-Hydroxybenzoic acid

4-Hydroxybenzoic acid
Names
	Preferred IUPAC name 4-Hydroxybenzoic acid
	Other names p-Hydroxybenzoic acid; para-Hydroxybenzoic acid; PHBA; 4-hydroxybenzoate
Identifiers
CAS Number	99-96-7 ;
3D model (JSmol)	Interactive image; Interactive image;
ChEBI	CHEBI:30763 ;
ChEMBL	ChEMBL441343 ;
ChemSpider	132 ;
DrugBank	DB04242 ;
ECHA InfoCard	100.002.550
EC Number	202-804-9;
IUPHAR/BPS	5783;
KEGG	C00156 ;
PubChem CID	135;
UNII	JG8Z55Y12H ;
CompTox Dashboard (EPA)	DTXSID3026647 ;
	InChI InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10) Key: FJKROLUGYXJWQN-UHFFFAOYSA-N ; InChI=1/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10) Key: FJKROLUGYXJWQN-UHFFFAOYAQ;
	SMILES O=C(O)c1ccc(O)cc1; c1cc(ccc1C(=O)O)O;
Properties
Chemical formula	C7H6O3
Molar mass	138.122 g·mol−1
Appearance	White crystalline
Odor	Odorless
Density	1.46 g/cm3
Melting point	214.5 °C (418.1 °F; 487.6 K)
Boiling point	N/A, decomposes
Solubility in water	0.5 g/100 mL
Solubility	Soluble in alcohol, ether, acetone; Slightly soluble in chloroform; Negligibly in CS2;
log P	1.58
Acidity (pKa)	4.54
Hazards
	Occupational safety and health (OHS/OSH):
Main hazards	Irritant
NFPA 704 (fire diamond)	2 0 0
Autoignition; temperature	250 °C (482 °F; 523 K)
	Lethal dose or concentration (LD, LC):
LD50 (median dose)	2200 mg/kg (oral, mouse)
Safety data sheet (SDS)	HMDB
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

4-Hydroxybenzoic acid, also known as p-hydroxybenzoic acid (PHBA), is a monohydroxybenzoic acid, a phenolic derivative of benzoic acid. It is a white crystalline solid that is slightly soluble in water and chloroform but more soluble in polar organic solvents such as alcohols and acetone. 4-Hydroxybenzoic acid is primarily known as the basis for the preparation of its esters, known as parabens, which are used as preservatives in cosmetics and some ophthalmic solutions. It is isomeric with 2-hydroxybenzoic acid, known as salicylic acid, a precursor to aspirin, and with 3-hydroxybenzoic acid.

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