4-Aminoquinoline
4-Aminoquinoline is a form of aminoquinoline with the amino group at the 4-position of the quinoline. The compound has been used as a precursor for the synthesis of its derivatives.
Names | |
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Preferred IUPAC name
Quinolin-4-amine | |
Identifiers | |
3D model (JSmol) |
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ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.167.771 |
PubChem CID |
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UNII | |
CompTox Dashboard (EPA) |
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SMILES
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Properties | |
C9H8N2 | |
Molar mass | 144.177 g·mol−1 |
Appearance | Powder to crystalline, White/Yellow/Orange |
Melting point | 151.0 to 155.0 °C |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards |
Causes skin and serious eye irritation |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references |
A variety of derivatives of 4-aminoquinoline are antimalarial agents useful in treating erythrocytic plasmodial infections. Examples include amodiaquine, chloroquine, and hydroxychloroquine. Other uses for the derivatives are: anti-asthmatic, antibacterial, anti-fungal, anti-malarial, antiviral and anti-inflammatory agents.
A patent application for 4-aminoquinoline compounds was filed in 2002 and published in 2005.
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