Amodiaquine

Amodiaquine
Clinical data
Trade names	Amdaquine, Amobin, Camoquin, others
AHFS/Drugs.com	International Drug Names
ATC code	P01BA06 (WHO) ;
Identifiers
	IUPAC name 4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol;
CAS Number	86-42-0 ;
PubChem CID	2165;
DrugBank	DB00613 ;
ChemSpider	2080 ;
UNII	220236ED28;
KEGG	D02922 ;
ChEBI	CHEBI:2674 ;
ChEMBL	ChEMBL682 ;
CompTox Dashboard (EPA)	DTXSID2022597 ;
ECHA InfoCard	100.001.518
Chemical and physical data
Formula	C20H22ClN3O
Molar mass	355.87 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1cc2nccc(c2cc1)Nc3cc(c(O)cc3)CN(CC)CC;
	InChI InChI=1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23) ; Key:OVCDSSHSILBFBN-UHFFFAOYSA-N ;
	(verify)

Amodiaquine (ADQ) is a medication used to treat malaria, including Plasmodium falciparum malaria when uncomplicated. It is recommended to be given with artesunate to reduce the risk of resistance. Due to the risk of rare but serious side effects, it is not generally recommended to prevent malaria. Though, the World Health Organization (WHO) in 2013 recommended use for seasonal preventive in children at high risk in combination with sulfadoxine and pyrimethamine.

Amodiaquine is a 4-aminoquinoline compound related to chloroquine. The side effects of amodiaquine are generally minor to moderate and are similar to those of chloroquine. Rarely liver problems or low blood cell levels may occur. When taken in excess headaches, trouble seeing, seizures, and cardiac arrest may occur. The WHO recommends its use for pregnant women during the second and third trimester as well as during lactation, but reports that evidence for use in the first trimester is still insufficient.

Amodiaquine was first made in 1948. It is on the World Health Organization's List of Essential Medicines. While not available in the United States, it is widely available in Africa.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.