2016 United States presidential election in Wyoming

The 2016 United States presidential election in Wyoming was held on November 8, 2016, as part of the 2016 United States presidential election in which all 50 states plus the District of Columbia participated. Wyoming voters chose electors to represent them in the Electoral College via a popular vote pitting the Republican Party's nominee, businessman Donald Trump, and running mate Indiana Governor Mike Pence against Democratic Party nominee, former Secretary of State Hillary Clinton and her running mate, Virginia Senator Tim Kaine.

On March 1 and April 9, 2016, in the presidential primaries, Wyoming voters expressed their preferences for the Democratic, Republican, Libertarian, and Constitution parties' respective nominees for president. Registered members of each party only voted in their party's primary, while voters who were unaffiliated chose any one primary in which to vote. Prior to the election, Wyoming was considered to be a state Trump would win or a safe red state.

Donald Trump won the election in Wyoming with 67.4% of the vote. Hillary Clinton received 21.6% of the vote. Gary Johnson of the Libertarian Party received 5.1%. Wyoming, a solidly Republican state, has not voted for a Democrat in a presidential election since it went for Lyndon B. Johnson in 1964. Trump carried every county with the exception of Teton County. His 46.3-point margin over Clinton not only made Wyoming the most Republican state in the 2016 election, but also the largest margin of victory by any presidential candidate in the state's history, besting Ronald Reagan's 42.3-point margin in 1984, though Ronald Reagan won the highest percentage in the state in 1984, winning an astonishing 70.5% of the vote. Clinton's 21.88% vote share was the lowest of any major party presidential nominee in Wyoming history.