2010 United States Senate election in Hawaii

The 2010 United States Senate election in Hawaii took place on November 2, 2010, concurrently with elections to the United States Senate in other states as well as elections to the United States House of Representatives and various state and local elections. The primary elections were held on September 18, 2010. Incumbent Senator Daniel Inouye, also the President pro tempore, secured the Democratic nomination with over 88 percent of the vote over his sole challenger, businessman Andy Woerner, while former state legislator (and Inouye's 2004 opponent) Campbell Cavasso won the Republican nomination with two-thirds of the primary vote.

Focuses of the campaign included Inouye's seniority and ability to direct federal resources to the state, as well as Cavasso's emphases on change and fiscal responsibility. Polling found Inouye with a large lead, although one poll gave the Democrat a lead of only thirteen points, greatly underestimating his share of the vote. Inouye won re-election to his ninth and final term, with nearly 75 percent of the vote to Cavasso's 21.6 percent. The Senator would not serve out his ninth term, as he died in December 2012 and was replaced by appointed then-Lieutenant governor Brian Schatz.