ALOX15

ALOX15
Identifiers
Aliases	ALOX15, 12-LOX, arachidonate 15-lipoxygenase, LOG15, 15-LOX-1, 15LOX-1, 15-LOX
External IDs	OMIM: 152392 MGI: 87997 HomoloGene: 44935 GeneCards: ALOX15
Gene location (Human)
Chr.	Chromosome 17 (human)
End	4,642,294 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	70,242,857 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; oocyte; ; secondary oocyte; ; right uterine tube; ; trachea; ; right lung; ; parietal pleura; ; anterior pituitary; ; pericardium; ; blood;
	Top expressed in
	olfactory epithelium; ; cervix; ; blood; ; corneal stroma; ; lens; ; conjunctival fornix; ; bone marrow; ; esophagus; ; white adipose tissue; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hepoxilin A3 synthase activity; iron ion binding; eoxin A4 synthase activity; dioxygenase activity; hepoxilin-epoxide hydrolase activity; metal ion binding; protein binding; oxidoreductase activity; phosphatidylinositol-4,5-bisphosphate binding; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; lipid binding; arachidonate 15-lipoxygenase activity; arachidonate 12(S)-lipoxygenase activity;
Cellular component	cytoplasm; cytosol; membrane; extrinsic component of cytoplasmic side of plasma membrane; lipid droplet; plasma membrane;
Biological process	cellular response to calcium ion; bone mineralization; leukotriene metabolic process; positive regulation of heterotypic cell-cell adhesion; positive regulation of actin filament polymerization; negative regulation of adaptive immune response; ossification; lipoxin A4 biosynthetic process; lipid metabolism; wound healing; phosphatidylethanolamine biosynthetic process; regulation of peroxisome proliferator activated receptor signaling pathway; response to endoplasmic reticulum stress; fatty acid metabolic process; apoptotic cell clearance; lipoxygenase pathway; hepoxilin biosynthetic process; regulation of engulfment of apoptotic cell; positive regulation of ERK1 and ERK2 cascade; inflammatory response; cellular response to interleukin-13; positive regulation of cell-substrate adhesion; arachidonic acid metabolic process; cytokine-mediated signaling pathway; long-chain fatty acid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	246
	11687
	ENSG00000161905
	ENSMUSG00000018924
	P16050
	P39654
	NM_001140
	NM_009660
	NP_001131
	NP_033790
	Wikidata
View/Edit Human	View/Edit Mouse

ALOX15 (also termed arachidonate 15-lipoxygenase, 15-lipoxygenase-1, 15-LO-1, 15-LOX-1) is, like other lipoxygenases, a seminal enzyme in the metabolism of polyunsaturated fatty acids to a wide range of physiologically and pathologically important products. ▼ Gene Function

Kelavkar and Badr (1999) stated that the ALOX15 gene product is implicated in antiinflammation, membrane remodeling, and cancer development/metastasis. Kelavkar and Badr (1999) described experiments yielding data that supported the hypothesis that loss of the TP53 gene, or gain-of-function activities resulting from the expression of its mutant forms, regulates ALOX15 promoter activity in human and in mouse, albeit in directionally opposite manners. These studies defined a direct link between ALOX15 gene activity and an established tumor-suppressor gene located in close chromosomal proximity. Kelavkar and Badr (1999) referred to this as evidence that 15-lipoxygenase is a mutator gene. ▼ Mapping

By PCR analysis of a human-hamster somatic hybrid DNA panel, Funk et al. (1992) demonstrated that genes for 12-lipoxygenase and 15-lipoxygenase are located on human chromosome 17, whereas the most unrelated lipoxygenase (5-lipoxygenase) was mapped to chromosome 10.

Kelavkar and Badr (1999) stated that the ALOX15 gene maps to 17p13.3 in close proximity to the tumor-suppressor gene TP53 (191170). In humans, it is encoded by the ALOX15 gene located on chromosome 17p13.3. This 11 kilobase pair gene consists of 14 exons and 13 introns coding for a 75 kilodalton protein composed of 662 amino acids. 15-LO is to be distinguished from another human 15-lipoxygenase enzyme, ALOX15B (also termed 15-lipoxygenase-2). Orthologs of ALOX15, termed Alox15, are widely distributed in animal and plant species but commonly have different enzyme activities and make somewhat different products than ALOX15.

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