ALOX15B

ALOX15B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NRE
Identifiers
Aliases	ALOX15B, 15-LOX-2, arachidonate 15-lipoxygenase, type B, arachidonate 15-lipoxygenase type B
External IDs	OMIM: 603697 MGI: 1098228 HomoloGene: 886 GeneCards: ALOX15B
Gene location (Human)
Chr.	Chromosome 17 (human)
End	8,049,134 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,088,669 bp
RNA expression pattern
	Top expressed in
	vulva; ; prostate; ; right lung; ; nipple; ; vagina; ; skin of abdomen; ; upper lobe of lung; ; upper lobe of left lung; ; lower lobe of lung; ; epithelium of esophagus;
	Top expressed in
	lip; ; hair follicle; ; superior frontal gyrus; ; cerebellar cortex; ; skin of abdomen; ; skin of back; ; atrioventricular valve; ; hippocampus proper; ; spinal cord; ; saccule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	iron ion binding; calcium ion binding; dioxygenase activity; metal ion binding; arachidonate 8(S)-lipoxygenase activity; linoleate 13S-lipoxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; lipid binding; arachidonate 15-lipoxygenase activity;
Cellular component	intracellular anatomical structure; extracellular exosome; extrinsic component of membrane; cytosol; nucleus; membrane; cytoskeleton; plasma membrane; cytoplasm;
Biological process	apoptotic process; linoleic acid metabolic process; negative regulation of growth; lipid metabolism; positive regulation of keratinocyte differentiation; negative regulation of cell cycle; prostate gland development; lipoxygenase pathway; hepoxilin biosynthetic process; positive regulation of macrophage derived foam cell differentiation; negative regulation of cell migration; positive regulation of peroxisome proliferator activated receptor signaling pathway; regulation of epithelial cell differentiation; negative regulation of cell population proliferation; arachidonic acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	247
	11688
	ENSG00000179593
	ENSMUSG00000020891
	O15296
	O35936
	NM_001141; NM_001039130; NM_001039131
	NM_009661
	NP_001034219; NP_001034220; NP_001132
	NP_033791
	Wikidata
View/Edit Human	View/Edit Mouse

Arachidonate 15-lipoxygenase type II is an enzyme that in humans is encoded by the ALOX15B gene. ALOX15B, also known as 15-lipoxygenase-2 (15-LO-2 or 15-LOX-2), is distinguished from its related oxygenase, ALOX15 or 15-lipoxygenase-1.

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