Alpha-1B adrenergic receptor

ADRA1B
Identifiers
Aliases	ADRA1B, ADRA1, ALPHA1BAR, adrenoceptor alpha 1B
External IDs	OMIM: 104220 MGI: 104774 HomoloGene: 55477 GeneCards: ADRA1B
Gene location (Human)
Chr.	Chromosome 5 (human)
End	159,973,012 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	43,792,037 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; thoracic aorta; ; ascending aorta; ; popliteal artery; ; prefrontal cortex; ; cingulate gyrus; ; right lung; ; spleen; ; Brodmann area 9; ; left uterine tube;
	Top expressed in
	left lobe of liver; ; superior frontal gyrus; ; right ventricle; ; lateral geniculate nucleus; ; medial dorsal nucleus; ; cardiac muscles; ; cerebellar cortex; ; calvaria; ; neural tube; ; primary motor cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; adrenergic receptor activity; protein heterodimerization activity; alpha1-adrenergic receptor activity; protein binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; nucleus; nuclear membrane; plasma membrane; cytoplasm; caveola;
Biological process	regulation of muscle contraction; intracellular signal transduction; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; glucose homeostasis; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; cell-cell signaling; multicellular organism development; adenylate cyclase-activating adrenergic receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; regulation of vasoconstriction; positive regulation of vasoconstriction; regulation of cardiac muscle contraction; cell population proliferation; positive regulation of smooth muscle contraction; positive regulation of MAPK cascade; signal transduction; G protein-coupled receptor signaling pathway; neuron-glial cell signaling;
	Sources:Amigo / QuickGO
Orthologs
	147
	11548
	ENSG00000170214
	ENSMUSG00000050541
	P35368
	P97717
	NM_000679
	NM_001284380; NM_001284381; NM_007416
	NP_000670
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

The alpha-1B adrenergic receptor (α_1B-adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it. The crystal structure of the α_1B-adrenergic receptor has been determined in complex with the inverse agonist (+)-cyclazosin.

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