CYP2R1

CYP2R1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3C6G, 3CZH, 3DL9
Identifiers
Aliases	CYP2R1, cytochrome P450 family 2 subfamily R member 1
External IDs	OMIM: 608713 MGI: 2449771 HomoloGene: 75210 GeneCards: CYP2R1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	14,892,231 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	114,162,207 bp
RNA expression pattern
	Top expressed in
	sperm; ; body of pancreas; ; skin of abdomen; ; body of stomach; ; rectum; ; ascending aorta; ; minor salivary glands; ; jejunal mucosa; ; tibia; ; Achilles tendon;
	Top expressed in
	left lobe of liver; ; spermatocyte; ; secondary oocyte; ; seminiferous tubule; ; proximal tubule; ; spermatid; ; duodenum; ; esophagus; ; lip; ; stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	iron ion binding; metal ion binding; monooxygenase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity; vitamin D3 25-hydroxylase activity; steroid hydroxylase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;
Cellular component	organelle membrane; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane; endoplasmic reticulum; cytoplasm;
Biological process	response to ionizing radiation; vitamin D metabolic process; response to metal ion; vitamin metabolic process; calcitriol biosynthetic process from calciol; response to cesium ion; organic acid metabolic process; xenobiotic metabolic process; vitamin D biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	120227
	244209
	ENSG00000186104
	ENSMUSG00000030670
	Q6VVX0
	Q6VVW9
NM_024514; NM_001377214; NM_001377215; NM_001377216; NM_001377217;
	NM_001377227
	NM_177382
NP_078790; NP_001364143; NP_001364144; NP_001364145; NP_001364146;
	NP_001364156
	NP_796356
	Wikidata
View/Edit Human	View/Edit Mouse

CYP2R1 is cytochrome P450 2R1, an enzyme which is the principal vitamin D 25-hydroxylase. In humans it is encoded by the CYP2R1 gene located on chromosome 11p15.2. It is expressed in the endoplasmic reticulum in liver, where it performs the first step in the activation of vitamin D by catalyzing the formation of 25-hydroxyvitamin D.

Vitamin D 25-hydroxylase activity is also possessed by some other cytochrome P450 enzymes, in particular CYP27A1, which is found in mitochondria.

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