Enterotoxin type B
In the field of molecular biology, enterotoxin type B, also known as Staphylococcal enterotoxin B (SEB), is an enterotoxin produced by the gram-positive bacteria Staphylococcus aureus. It is a common cause of food poisoning, with severe diarrhea, nausea and intestinal cramping often starting within a few hours of ingestion. Being quite stable, the toxin may remain active even after the contaminating bacteria are killed. It can withstand boiling at 100 °C for a few minutes. Gastroenteritis occurs because SEB is a superantigen, causing the immune system to release a large amount of cytokines that lead to significant inflammation.
| Enterotoxin type B | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | entB | ||||||
| UniProt | P01552 | ||||||
| |||||||
| Staphylococcal/Streptococcal toxin, N-terminal domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Crystal structure of the superantigen Spe-H (zinc bound) from Streptococcus pyogenes | |||||||||
| Identifiers | |||||||||
| Symbol | Staphylococcal/Streptococcal toxin, N-terminal domain | ||||||||
| Pfam | PF01123 | ||||||||
| InterPro | IPR006173 | ||||||||
| PROSITE | PDOC00250 | ||||||||
| SCOP2 | 1se3 / SCOPe / SUPFAM | ||||||||
| |||||||||
| Staphylococcal/Streptococcal toxin, beta-grasp domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Stap_Strp_tox_C | ||||||||
| Pfam | PF02876 | ||||||||
| InterPro | IPR006123 | ||||||||
| PROSITE | PDOC00250 | ||||||||
| SCOP2 | 1se3 / SCOPe / SUPFAM | ||||||||
| |||||||||
Additionally, this protein is one of the causative agents of toxic shock syndrome.
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