cGMP-dependent protein kinase
cGMP-dependent protein kinase or protein kinase G (PKG) is a serine/threonine-specific protein kinase that is activated by cGMP. It phosphorylates a number of biologically important targets and is implicated in the regulation of smooth muscle relaxation, platelet function, sperm metabolism, cell division, and nucleic acid synthesis.
| protein kinase, cGMP-dependent, type I | |||||||
|---|---|---|---|---|---|---|---|
Crystallographic structure of the leucine zipper domain of human cGMP dependent protein kinase I beta. | |||||||
| Identifiers | |||||||
| Symbol | PRKG1 | ||||||
| Alt. symbols | PRKGR1B, PRKG1B | ||||||
| NCBI gene | 5592 | ||||||
| HGNC | 9414 | ||||||
| OMIM | 176894 | ||||||
| RefSeq | NM_006258 | ||||||
| UniProt | Q13976 | ||||||
| Other data | |||||||
| Locus | Chr. 10 q11.2 | ||||||
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| protein kinase, cGMP-dependent, type II | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PRKG2 | ||||||
| NCBI gene | 5593 | ||||||
| HGNC | 9416 | ||||||
| OMIM | 601591 | ||||||
| RefSeq | NM_006259 | ||||||
| UniProt | Q13237 | ||||||
| Other data | |||||||
| Locus | Chr. 4 q13.1-21.1 | ||||||
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