Cytosol nonspecific dipeptidase

Cytosolic non-specific dipeptidase (EC 3.4.13.18) also known as carnosine dipeptidase 2 is an enzyme that in humans is encoded by the CNDP2 gene. This enzyme catalyses the hydrolysis of dipeptides, preferentially those containing hydrophobic amino acids. The human enzyme uses manganese ions as a cofactor. In addition to its function as a peptidase, the enzyme also functions to generate N-lactoyl amino acids, such as N-lactoyl-phenylalanine, via the process of "reverse proteolysis".

CNDP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCNDP2, CN2, CPGL, HEL-S-13, HsT2298, PEPA, CNDP dipeptidase 2 (metallopeptidase M20 family), carnosine dipeptidase 2
External IDsOMIM: 169800 MGI: 1913304 HomoloGene: 10085 GeneCards: CNDP2
Orthologs
SpeciesHumanMouse
Entrez

55748

66054

Ensembl

ENSG00000133313

ENSMUSG00000024644

UniProt

Q96KP4

Q9D1A2

RefSeq (mRNA)

NM_001289531
NM_023149

RefSeq (protein)

NP_001276460
NP_075638

Location (UCSC)Chr 18: 74.5 – 74.52 MbChr 18: 84.69 – 84.7 Mb
PubMed search
Wikidata
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Cytosol nonspecific dipeptidase
Identifiers
EC no.3.4.13.18
CAS no.9025-31-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
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