COQ7

COQ7
Identifiers
Aliases	COQ7, CAT5, CLK-1, CLK1, COQ10D8, coenzyme Q7, hydroxylase
External IDs	OMIM: 601683 MGI: 107207 HomoloGene: 6953 GeneCards: COQ7
Gene location (Human)
Chr.	Chromosome 16 (human)
End	19,080,095 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	118,132,579 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; Achilles tendon; ; left ventricle; ; ganglionic eminence; ; triceps brachii muscle; ; rectum; ; gastric mucosa; ; sural nerve; ; left adrenal gland; ; left uterine tube;
	Top expressed in
	facial motor nucleus; ; right ventricle; ; digastric muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; soleus muscle; ; myocardium of ventricle; ; endocardial cushion; ; renal corpuscle; ; intercostal muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; chromatin binding; protein binding; metal ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity;
Cellular component	mitochondrial inner membrane; mitochondrion; nucleus; membrane; extrinsic component of mitochondrial inner membrane;
Biological process	negative regulation of transcription by RNA polymerase II; regulation of reactive oxygen species metabolic process; positive regulation of transcription by RNA polymerase II; ubiquinone biosynthetic process; mitochondrial ATP synthesis coupled electron transport; determination of adult lifespan; regulation of gene expression;
	Sources:Amigo / QuickGO
Orthologs
	10229
	12850
	ENSG00000167186
	ENSMUSG00000030652
	Q99807
	P97478
	NM_001190983; NM_016138
	NM_009940; NM_001304758
NP_001177912; NP_057222; NP_001357418; NP_001357419; NP_001357420;
	NP_001357421; NP_001357422; NP_001357423; NP_001357424
	NP_001291687; NP_034070
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial 5-demethoxyubiquinone hydroxylase (DMQ hydroxylase), also known as coenzyme Q7, hydroxylase, is an enzyme that in humans is encoded by the COQ7 gene. The clk-1 (clock-1) gene encodes this protein that is necessary for ubiquinone biosynthesis in the worm Caenorhabditis elegans and other eukaryotes. The mouse version of the gene is called mclk-1 and the human, fruit fly and yeast homolog COQ7 (coenzyme Q biosynthesis protein 7).

CLK-1 is not to be confused with the unrelated human protein CLK1 which plays a role in RNA splicing.

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