ABCC4

ABCC4
Identifiers
Aliases	ABCC4, MOAT-B, MOATB, MRP4, ATP binding cassette subfamily C member 4
External IDs	OMIM: 605250 MGI: 2443111 HomoloGene: 74563 GeneCards: ABCC4
Gene location (Human)
Chr.	Chromosome 13 (human)
End	95,301,475 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	118,943,631 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; secondary oocyte; ; corpus epididymis; ; kidney tubule; ; mucosa of urinary bladder; ; stromal cell of endometrium; ; lower lobe of lung; ; prostate; ; glomerulus; ; metanephric glomerulus;
	Top expressed in
	conjunctival fornix; ; olfactory epithelium; ; lacrimal gland; ; iris; ; ciliary body; ; retinal pigment epithelium; ; cornea; ; secondary oocyte; ; uterus; ; otolith organ;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; ATPase activity; ATP binding; 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; ATPase-coupled inorganic anion transmembrane transporter activity; P-type ion transporter activity; ATPase-coupled transmembrane transporter activity; protein binding;
Cellular component	integral component of membrane; platelet dense granule membrane; membrane; plasma membrane; basolateral plasma membrane; integral component of plasma membrane;
Biological process	prostaglandin secretion; platelet degranulation; response to organic cyclic compound; response to organic substance; positive regulation of smooth muscle cell proliferation; response to organonitrogen compound; transmembrane transport; cilium assembly; transport; ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	10257
	239273
	ENSG00000125257
	ENSMUSG00000032849
	O15439
	E9Q236
	NM_001105515; NM_001301829; NM_001301830; NM_005845
	NM_001033336; NM_001163675; NM_001163676
	NP_001098985; NP_001288758; NP_001288759; NP_005836
	NP_001028508; NP_001157147; NP_001157148
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-binding cassette sub-family C member 4 (ABCC4), also known as the multidrug resistance-associated protein 4 (MRP4) or multi-specific organic anion transporter B (MOAT-B), is a protein that in humans is encoded by the ABCC4 gene.

ABCC4 acts as a regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. MRP4/ABCC4 also transports prostaglandins, for example PGE2, out of the cell where they can bind receptors.

MRP4/ABCC4 expression is dysregulated in several cancers and is also upregulated in peritoneal endometriosis.

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