Atropine/diphenoxylate

Atropine/diphenoxylate
Combination of
Diphenoxylate	Mu opiate receptor agonist
Atropine	Muscarinic acetylcholine receptors antagonist
Clinical data
Trade names	Lomotil
AHFS/Drugs.com	Professional Drug Facts
License data	US DailyMed: Diphenoxylate hydrochloride and atropine sulfate;
Pregnancy; category	AU: C;
Routes of; administration	By mouth
ATC code	None;
Legal status
Legal status	UK: POM (Prescription only); US: Schedule V;
Identifiers
CAS Number	55840-97-6;
PubChem CID	23724775;
ChemSpider	none;
KEGG	D00301;
ChEBI	CHEBI:6519;
	(verify)

Diphenoxylate/atropine, also known as co-phenotrope, is a combination of the medications diphenoxylate and atropine, used to treat diarrhea. It should not be used in those in whom Clostridioides difficile infection is a concern. It is taken by mouth. Onset is typically within an hour.

Side effects may include abdominal pain, angioedema, glaucoma, heart problems, feeling tired, dry mouth, and trouble seeing. It is unclear if use in pregnancy is safe and use when breastfeeding may result in side effects in the baby. It works by decreasing contractions of the bowel.

The combination was approved for medical use in the United States in 1960. It is available as a generic medication. In 2021, it was the 293rd most commonly prescribed medication in the United States, with more than 600,000 prescriptions. It is sold under the brand name Lomotil among others. The medication is in Schedule V in the United States.

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