LEM domain-containing protein 3

LEMD3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CH0
Identifiers
Aliases	LEMD3, MAN1, LEM domain containing 3, LEM domain-containing protein 3
External IDs	OMIM: 607844 MGI: 3580376 HomoloGene: 8633 GeneCards: LEMD3
Gene location (Human)
Chr.	Chromosome 12 (human)
End	65,248,355 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	120,815,237 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; cerebellar vermis; ; germinal epithelium; ; visceral pleura; ; superficial temporal artery; ; spongy bone; ; Brodmann area 23; ; tibia; ; parietal pleura; ; middle temporal gyrus;
	Top expressed in
	hand; ; cerebellar vermis; ; ventromedial nucleus; ; piriform cortex; ; suprachiasmatic nucleus; ; superior cervical ganglion; ; habenula; ; cumulus cell; ; mammillary body; ; primary motor cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein binding; nucleic acid binding; chromatin DNA binding;
Cellular component	integral component of membrane; nuclear inner membrane; membrane; nucleus; nuclear membrane; integral component of nuclear inner membrane;
Biological process	negative regulation of activin receptor signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of BMP signaling pathway; nuclear envelope organization; meiotic attachment of telomere to nuclear envelope; angiogenesis; nucleus organization; regulation of intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	23592
	380664
	ENSG00000174106
	ENSMUSG00000048661
	Q9Y2U8
	Q9WU40
	NM_014319; NM_001167614
	NM_001081193
	NP_001161086; NP_055134; NP_055134.2
	NP_001074662
	Wikidata
View/Edit Human	View/Edit Mouse

LEM domain-containing protein 3 (LEMD3), also known as MAN1, is an integral protein in the inner nuclear membrane (INM) of the nuclear envelope. It is encoded by the LEMD3 gene and was first identified after it was isolated from the serum of a patient with a collagen vascular disease.

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