K_ir6.2

KCNJ11
Identifiers
Aliases	KCNJ11, BIR, HHF2, IKATP, KIR6.2, MODY13, PHHI, TNDM3, potassium voltage-gated channel subfamily J member 11, potassium inwardly rectifying channel subfamily J member 11, PNDM2
External IDs	OMIM: 600937 MGI: 107501 HomoloGene: 441 GeneCards: KCNJ11
Gene location (Human)
Chr.	Chromosome 11 (human)
End	17,389,331 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,750,188 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; tibialis anterior muscle; ; islet of Langerhans; ; prefrontal cortex; ; left ventricle; ; skeletal muscle tissue; ; Brodmann area 9; ; cingulate gyrus; ; body of pancreas; ; body of stomach;
	Top expressed in
	medial ganglionic eminence; ; molar; ; calvaria; ; triceps brachii muscle; ; temporal muscle; ; ankle; ; intercostal muscle; ; major salivary gland; ; ankle joint; ; parotid gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	transmembrane transporter binding; potassium ion binding; voltage-gated ion channel activity; ankyrin binding; voltage-gated potassium channel activity; ATP-activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; ATP binding; protein binding; protein C-terminus binding; heat shock protein binding;
Cellular component	integral component of membrane; cytosol; endosome; nuclear envelope; membrane; intracellular membrane-bounded organelle; intercalated disc; cell body fiber; T-tubule; myelin sheath; plasma membrane; integral component of plasma membrane; neuronal cell body; endoplasmic reticulum; mitochondrion; axolemma; inward rectifying potassium channel; sarcolemma; acrosomal vesicle;
Biological process	positive regulation of cation channel activity; response to ATP; response to estradiol; negative regulation of insulin secretion; regulation of insulin secretion; response to testosterone; regulation of membrane potential; cellular response to tumor necrosis factor; regulation of ion transmembrane transport; nervous system process; cellular response to nicotine; ion transport; potassium ion transport; response to ischemia; potassium ion transmembrane transport; glucose metabolic process; cellular response to glucose stimulus; positive regulation of protein localization to plasma membrane; potassium ion import across plasma membrane; transmembrane transport; regulation of cardiac conduction;
	Sources:Amigo / QuickGO
Orthologs
	3767
	16514
	ENSG00000187486
	ENSMUSG00000096146
	Q14654
	Q61743
	NM_000525; NM_001166290; NM_001377296; NM_001377297
	NM_001204411; NM_010602
	NP_000516; NP_001159762; NP_001364225; NP_001364226
	NP_001191340; NP_034732
	Wikidata
View/Edit Human	View/Edit Mouse

K_ir6.2 is a major subunit of the ATP-sensitive K⁺ channel, a lipid-gated inward-rectifier potassium ion channel. The gene encoding the channel is called KCNJ11 and mutations in this gene are associated with congenital hyperinsulinism.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

Kir6.2

K_ir6.2