KiSS1-derived peptide receptor

KISS1R
Identifiers
Aliases	KISS1R, AXOR12, CPPB1, GPR54, HH8, HOT7T175, KISS-1R, KiSS1-derived peptide receptor, KISS1 receptor
External IDs	OMIM: 604161 MGI: 2148793 HomoloGene: 11411 GeneCards: KISS1R
Gene location (Human)
Chr.	Chromosome 19 (human)
End	921,005 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,758,107 bp
RNA expression pattern
	Top expressed in
	pons; ; endothelial cell; ; hypothalamus; ; Brodmann area 23; ; pancreatic ductal cell; ; superior vestibular nucleus; ; nucleus accumbens; ; blood; ; cingulate gyrus; ; entorhinal cortex;
	Top expressed in
	substantia nigra; ; neuron; ; superior frontal gyrus; ; cerebellar cortex; ; suprachiasmatic nucleus; ; supraoptic nucleus; ; stria vascularis; ; hippocampus proper; ; habenula; ; placenta;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled peptide receptor activity; G protein-coupled receptor activity; neuropeptide receptor activity; signal transducer activity; protein binding;
Cellular component	integral component of membrane; intracellular membrane-bounded organelle; membrane; plasma membrane; integral component of plasma membrane; cell surface; cilium;
Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway; signal transduction; neuropeptide signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	84634
	114229
	ENSG00000116014
	ENSMUSG00000035773
	Q969F8
	Q91V45
	NM_032551
	NM_053244; NM_001359010
	NP_115940
	NP_444474; NP_001345939
	Wikidata
View/Edit Human	View/Edit Mouse

The KiSS1-derived peptide receptor (also known as GPR54 or the Kisspeptin receptor) is a G protein-coupled receptor which binds the peptide hormone kisspeptin (metastin). Kisspeptin is encoded by the metastasis suppressor gene KISS1, which is expressed in a variety of endocrine and gonadal tissues. Activation of the kisspeptin receptor is linked to the phospholipase C and inositol trisphosphate second messenger cascades inside the cell.

Kisspeptins are neuropeptides synthesized in the hypothalamus and encoded by the KISS1 gene. The KISS1 gene encodes the G protein-coupled receptor 54 (known as KISS1R or GPR54) and plays a crucial role in regulating reproduction, pubertal maturation, and metabolic function. KISS1 neurons located in the arcuate nucleus (ARC) of the mediobasal hypothalamus (MBH) project to GnRH neurons in the median eminence, which expresses KISS1R, to stimulate LH secretions in a pulsatile manner from the anterior pituitary to initiate ovulation/ pubertal maturation. The KISS1 and KISS1R/GPR54 genes have been detected in the brain, pituitary, placenta, pancreas, liver, and small intestine.

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