Keratin 14

KRT14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3TNU
Identifiers
Aliases	KRT14, CK14, EBS3, EBS4, K14, NFJ, keratin 14, EBS1D, EBS1, EBS1B, EBS1A, EBS1C
External IDs	OMIM: 148066 MGI: 96688 HomoloGene: 110439 GeneCards: KRT14
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,586,895 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	100,098,374 bp
RNA expression pattern
	Top expressed in
	nipple; ; vulva; ; human penis; ; hair follicle; ; skin of abdomen; ; body of tongue; ; cervix epithelium; ; palpebral conjunctiva; ; periodontal fiber; ; superior surface of tongue;
	Top expressed in
	lip; ; molar; ; skin of abdomen; ; skin of back; ; esophagus; ; cervix; ; conjunctival fornix; ; cornea; ; belly cord; ; condyle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of cytoskeleton; protein binding; keratin filament binding; structural molecule activity;
Cellular component	cytoplasm; cytosol; keratin filament; extracellular exosome; intermediate filament; intracellular anatomical structure; nucleus; cell periphery; basal part of cell;
Biological process	response to ionizing radiation; hemidesmosome assembly; hair cycle; human ageing; response to zinc ion; epithelial cell differentiation; intermediate filament bundle assembly; epidermis development; keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3861
	16664
	ENSG00000186847
	ENSMUSG00000045545
	P02533
	Q61781
	NM_000526
	NM_016958; NM_001313956; NM_001313957
	NP_000517
	NP_001300885; NP_001300886; NP_058654
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin 14 is a member of the type I keratin family of intermediate filament proteins. Keratin 14 was the first type I keratin sequence determined. Keratin 14 is also known as cytokeratin-14 (CK-14) or keratin-14 (KRT14). In humans it is encoded by the KRT14 gene.

Keratin 14 is usually found as a heterodimer with type II keratin 5 and form the cytoskeleton of epithelial cells.

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